فهرست نشریات علمی دسترسی آزاد ایران

An efficient and simple one-pot approach for the synthesis of 3,4-dihydropyrimidin-2-(1 H )-one derivatives using antimony trichloride (SbCl 3 ) as a mild catalyst by means of three-component Biginelli reaction between β-keto esters, aldehyde derivatives and urea/thiourea under thermal and solvent-free conditions with excellent yields and short reaction times is reported. This methodology offers several merits such as excellent yields, short reaction times, efficient, eco-friendly, solvent-free conditions, materials available, and simple operational procedure with no column chromatographic separation. The products are characterized by melting points and 1 H NMR spectroscopy.