Phosphotungstic Acidcatalyzed Strecker Three-Component Reaction of Amino Acids, Aldehydes, and Trimethylsilyl Cyanide
نویسندگان
1 دانشگاه پیام نور
2 دانشگاه حکیم سبزواری
3 دانشگاه رازی
doi
10.22036/org.chem..2015.10660چکیده
A simple and efficient one-pot, three-component Strecker reaction of protected amino acids, aromatic aldehydes, and trimethylsilyl cyanide has been developed for the synthesis of chiral α -amino nitriles. The reaction was carried out in the presence of catalytic amount of phosphotungstic acid (H 3 [P(W 3 O 10 ) 4 ]) as an environmentally friendly catalyst.
