Preparation and characterization of gelatin/ sodium alginate with thymus Kotschyanus hydrogel for wound healing, In Vitro study
نویسندگان
1 Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 Nanobiotechnology Department, Faculty of Innovative Science and Technology, Razi University Kermanshah, Iran
3 Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
4 Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
5 Fertility and Infertility Research Center, Research Institute for Health Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran
6 Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
doi
10.22038/nmj.2025.83422.2088چکیده
Objective(s): Gelatin / Sodium Alginate Thymus kotschyanus (GE/SA T. kotschyanus) hydrogel was prepared for use as a wound healing.Materials and Methods: The hydrogel was prepared by casting and cross-linking method and the physicochemical and the antimicrobial properties of the hydrogels were determined.Results: The GE/SA hydrogel showed high mechanical properties, while the addition of the extract to the hydrogel led to the relaxation of the polymer network and thus increased the elasticity of the dressing, and it had a good biodegradation. The compatibility of hydrogels with fibroblast cells was confirmed by MTT assay. Also, GE/SA T. kotschyanus hydrogels were found to be excellent Hemocompatibile. Moreover, these hydrogels exhibited the antibacterial activity against Pseudomonas aeruginosa, and Escherichia coli. In addition, these hydrogels showed the best antifungal effect against Candida albicans.Conclusion: The GE/SA T. kotschyanus hydrogels had the potential for use in wound dressing.
