Preparation and characterization of electrospun apigenin-loaded polycaprolactone nanofibers for wound dressing applications
نویسندگان
1 Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
2 Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
3 Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
4 Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
5 Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
6 Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
7 Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
doi
10.22038/nmj.2024.76451.1863چکیده
Objective(s): This study uses the blend-electrospinning method to explore the development of apigenin)APG(-loaded PCL nanofibers as a promising wound dressing material. Materials and Methods: The approach combines APG’s anti-inflammatory and antioxidant properties with the advantages of nanofibers for wound healing. The research investigates the electrospinning process for optimal parameters and characterizes the resulting nanofibers using FE-SEM, FTIR, and contact angle measurements. Results: The findings demonstrate successful APG incorporation into PCL nanofibers at concentrations up to 0.5 wt%. The APG release profile indicates a sustained release over 48 hours. Biocompatibility and cytotoxicity assessments using the Alamar Blue assay reveal excellent biocompatibility of APG-loaded PCL nanofibers (over 90% viability). Additionally, the nanofibers exhibit a porous, bead-free structure with improved hydrophilicity due to APG incorporation. Conclusion: Overall, this study highlights the development of APG/PCL nanofibers with promising characteristics for wound dressing applications. The combination of APG’s therapeutic properties, sustained release profile, and biocompatible nanofiber structure suggests their potential for effective wound healing.
