Syntehsis and evaluation of Gd3+ -Trp-PLGA as novel nanosized MR tumor imaging candidate
نویسندگان
1 Department of Pharmaceutics & Medical Nanotechnology, Branch of Pharmaceutical Sciences, Islamic Azad University, Tehran, Iran
2 Department of Pharmaceutics & Medical Nanotechnology, Branch of Pharmaceutical Sciences, Islamic Azad University, Tehran, Iran
3 Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
4 Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
5 Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
6 Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
7 Quality Control Department, Pasteur Institute of Iran
8 Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
9 Iran ministry of health and medical education, deputy ministry for education,Tehran , Iran
doi
10.22038/nmj.2021.08.004چکیده
Objective(s): Early detection of cancer can significantly increase the likelihood of successful treatment, and imaging assay can have a significant impact on cancer diagnosis. Although gadolinium compounds are used as a contrast agent in MRI, this substance has side effects and disadvantages. Nanotechnology has so far had a significan impact on medical imaging methods, especially MRI, nanoparticles are contrast enhancers that Each with its characteristics have increased the quality of images and reduced toxicity.Materials and Methods: In this study, a novel nano-conjugate based PLGA-tryptophan was synthesized and loaded with Gd3+ for using it as a potential MR imaging contrast agent to overcome the previous disadvantage. In vitro cell toxicity, cellular uptake and MR imaging parameters of the prepared nanoconjugate were investigated ,Results: The results showed no in vivo toxicity plus flowcytometry assays, good cellular uptake and large longitudinal (r1).Conclusion: Convenient features of the nano-probe indicate that it is a promising agent to use as a MR imaging agent.
