فهرست نشریات علمی دسترسی آزاد ایران

Echis carinatus (Saw-scale viper) is one of the most venomous snakes in Asia and someparts of the Africa with deadly hemotoxic venom. It has been reported that suramin, an antitrypansomiasisdrug, can inhibits the toxic effects of some snake venoms. This study wasconducted to evaluate the antagonistic effects of suramin against the venom of the Iraniansnake Echis carinatus.Adult albino mice weighing 35±5g were divided into nine groups (A1, A2, B1, B2, B3, C1,C2, D and E) of 6-10 mice. Groups A1 and A2 (protocol A), which received the venom at 7 and13 mg/kg, succumbed after 169±32 min and 53±16 min, respectively. Groups B1, B2 and B3(protocol B) were treated with different doses of suramin 15 min after injection of venom.The results show that suramin significantly delayed time to death in groups B1, B2 and B3compared with groups A1 and A2 (P