Antinociceptive effect of chronic administration of the flavonoid hesperetin in diabetic rats: Behavioral evidence
نویسندگان
1 Professor, Department of Physiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
2 M.D. Student, Faculty of Medicine, Shahed University, Tehran, Iran
3 Associate Professor, Department of Physiology and Medicinal Plant Research Center, Faculty of Medicine, Shahed University, Tehran, Iran
doi
چکیده
Objective: This study was designed to investigate the antinociceptive effect of chronic administration of the flavonoid hesperetin in streptozotocin-diabetic rats using formalin and hot tail immersion tests. Materials and Methods: Rats were divided into 5 control groups, hesperetin-treated control, diabetic, sodium salicylate (SS)-treated diabetic, and hesperetin- and glibenclamide-treated diabetic groups. Hesperetin (10 mg/kg) was administered i.p. one other day 1 week after diabetes induction for 6 weeks. Finally, thermal pain tolerance and nociception were evaluated using hot water tail immersion and formalin tests respectively. Results: Diabetic rats exhibited a higher score of pain at both phases of the formalin test (P<0.05) and hesperetin-treated diabetic rats exhibited a lower nociceptive score at both phases of the test (P<0.05). Regarding thermal pain tolerance, diabetes significantly reduced tail immersion latency (P<0.01) and hesperetin treatment did produce a significant change in this respect (P<0.05). Conclusion: Chronic treatment with hesperetin for 6 weeks does mildly increase thermal pain tolerance and reduces chemical nociception in an experimental model of diabetes mellitus and this may be considered as an auxiliary treatment for diabetic hyperalgesia.
