Comparison of C - reactive protein Levels in Chronic Periodontitis Patients with Normal Subjects
نویسندگان
1 Assistant Professor,Periodontology Department, Oral and Dental Disease Research Center, Zahedan University of Medical Sciences, Zahedan, IR Iran
2 Associate Professor,Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, IR Iran
3 Student of Dentistry, Tabriz University of Medical Sciences, Tabriz, IR Iran 3DMD, private practice
4 General Dentists, Zahedan University of Medical Sciences, Zahedan, IR Iran
5 Assistant Professor,Oral and Maxillofacial Surgery Department, Oral and Dental Disease Research Center, Zahedan University of Medical Sciences, Zahedan, IR Iran
doi
10.22038/jdmt.2017.9416چکیده
Background: Chronic periodontitis causes systemic inflammation and increases C-reactive protein (CRP). CRP has been implicated as a possible mediator of associating periodontitis and several systemic diseases. The aim of the present study was to investigate systemic levels of CRP in patients with chronic periodontitis in comparison to periodontally healthy individuals. Materials and methods: A total of 80 individuals were included in this study. 40 patients with severe chronic periodontitis aged 40, and 40 sex matched periodontally healthy subjects were recruited from the patients attending Dpartment of Periodontics, Faculty of Dentistry, Zahedan. Body Mass Index (BMI) was under 25 kg/m2 in all the patients and controls. Peripheral blood samples were taken and CRP levels were estimated in serum samples using the C - reactive protein – hs (CRP-hs) LATEX – High sensitivity (Biosystem S.A). Result: CRP levels in women in the test group (3.64 +- 2.77 mg/l) was significantly higher than the women in the control group (p < 0.001); however, the difference between males in the two study groups was not significant (p=0.13). Conclusion: Periodontitis results in higher systemic levels of CRP. Elevated inflammatory factor may increase inflammatory activity in atherosclerotic lesions and potentially increase the risk for cardiovascular events.
