Biochemical parameters of rat blood during cadmium intoxication and subsequent correction with Tagansorbent
نویسندگان
1 Medical center Talmas Medicus, Astana, Kazakhstan
2 Department of Physical Culture and Informatics, Institute of education and management, West Kazakhstan Innovative Technological University, Uralsk, Kazakhstan
3 Department of Biology, Faculty of Natural Sciences and Geography, Abai Kazakh National Pedagogical University
4 Department of Anatomy with courses, Kazakh-Russian Medical University, Almaty, Kazakhstan
5 Kazakh-Russian Medical University, Almaty, Kazakhstan
6 Department of Biology, Faculty of Natural Sciences and Geography, Abai Kazakh National Pedagogical University
7 Department of Biology, Faculty of Natural Sciences and Geography, Abai Kazakh National Pedagogical University
doi
10.22124/cjes.2025.9363چکیده
The aim of this research was to investigate the protective effects of Tagansorbent on cadmium poisoning-induced biochemical disorders in rats. In this experimental study, 40 rats were divided into four groups and received treatment for 14 days. The results showed that cadmium poisoning highly significantly increased liver enzymes, including ALT, AST, and ALP. Renal function indices also revealed significant increases, including urea and creatinine. All these parameters were significantly improved in the group treated with Tagansorbent along with cadmium. Besides, Tagansorbent significantly reduced the level of malondialdehyde and increased the total antioxidant capacity in the liver tissue (p < 0.01). The findings of the current study demonstrated that Tagansorbent could reduce the toxic effects of this element on the liver and kidney through multiple mechanisms such as cadmium absorption and reduction of oxidative stress, and thus can be considered as an auxiliary agent in the management of cadmium poisoning.
