Ethnobotanical study on medicinal plants used for Asthma: Systematic review on current knowledge
نویسندگان
1 PhD, Associate Professor of the Department Clinic Pharmacology of the Bukhara State Medical Institute Named After Abu Ali Ibn Sino of Uzbekistan
2 Andijan Machine- Building Institute, Str. Boburshoh 56, Andijan, Uzbekistan, 170100
3 PhD, Associate Professor of the Department of Botany, Biotechnology and Ecology, Faculty of Natural Sciences, Fergana State University, Uzbekistan
4 Tashkent State Technical University Named After Islam Karimov, Str. University 2, Tashkent 100095, Uzbekistan
5 Senior Lecturer of
6 University of Tashkent for Applied Sciences, Str. Gavhar 1, Tashkent 100149, Uzbekistan
7 Professor of the Namangan Institute of Engineering and Technology, Uzbekistan
8 Associate Professor of the Department of Use of Hydromelioration Systems, Tashkent Institute of Irrigation and Agricultural Mechanization Engineers, National Research University, Tashkent, Uzbekistan & Western Caspian University, Scientific researcher, Baku, Azerbaijan
9 Oncologist, Pediatric Oncosurgery, Interventional Oncologist, Scientific Researcher in Department of
10 PhD, Associate Professor of the Department of Botany, Biotechnology and Ecology, Faculty of Natural Sciences, Fergana State University, Uzbekistan
doi
10.22124/cjes.2025.8353چکیده
This systematic review explores the ethnobotanical knowledge surrounding medicinal plants utilized in the treatment of asthma. The study highlights the significance of various phytochemicals, including polyphenols, alkaloids, and terpenoids, in managing asthma symptoms. Research indicates that polyphenols, such as curcumin, exhibit anti-inflammatory properties by modulating cytokine levels and reducing eosinophil recruitment, alleviating airway hyperresponsiveness and inflammation. Alkaloids, particularly total alkaloids from Alstonia scholaris, have shown promise in diminishing pulmonary inflammation and restoring the balance of Th1, Th2, and Th17 cytokines, which are crucial in asthma pathophysiology. Furthermore, terpenoids like astragaloside IV and paeoniflorin have demonstrated efficacy in reducing airway hyperresponsiveness and eosinophilia while promoting a shift towards a Th1 phenotype, thus enhancing the immune response against asthma. The findings underscore the potential of these natural compounds as therapeutic agents in asthma management, emphasizing the need for further research to validate their efficacy and mechanisms of action. This review serves as a comprehensive resource for understanding the current knowledge of medicinal plants in asthma treatment, paving the way for future studies to integrate traditional knowledge with modern pharmacological approaches.
