Pichia pastoris an Ideal Host for the Production of Recombinant Influenza Vaccines
نویسندگان
1 Department of Avian Health and Diseases, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
2 Department of Animal Science, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran.
3 Department of Avian Health and Diseases, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
4 Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5 Department of Avian Health and Diseases, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
doi
10.32598/ijvm.18.4.1005523چکیده
Pichia pastoris is a methylotrophic yeast with remarkable characteristics such as lacking endotoxin, producing high amounts of recombinant protein, performing post-translational modifications, and so on. Influenza A virus, a member of the Orthomyxoviridae family, is the cause of avian influenza. Three avian influenza virus subtypes, H5, H7 and H9, are commercially and physiologically significant in the poultry industry. Some researchers considered influenza to be the next pandemic disease. Nowadays, researchers have paid attention to producing novel and effective recombinant vaccines, especially in the poultry industry. Due to the advantages of P. pastoris yeast, it can be used as an ideal expression system for producing subunit vaccines. Although several studies have been conducted in this field, there is no comprehensive review of using P. pastoris to produce recombinant influenza vaccines. This review explains the different strains, phenotypes, and advantages of this yeast and then the production of recombinant influenza vaccines using this expression system is discussed in detail.
