Synthesis, structure, and properties of platinum(II) complexes with monoethanolamine
نویسندگان
1 Azerbaijan Medical University, Research Center, Baku, Azerbaijan.
2 Western Caspian University, Baku, Azerbaijan.
3 Azerbaijan Medical University, Research Center, Baku, Azerbaijan.
4 Western Caspian University, Baku, Azerbaijan.
5 AMU, Department of Pharmaceutical Toxicology and Chemistry, Baku, Azerbaijan.
6 Azerbaijan Medical University, Research Center, Baku, Azerbaijan.
doi
10.22034/crl.2025.549425.1700چکیده
New complex compounds of platinum (II) with the biologically active ligand monoethanolamine (HL), featuring cis-, trans- [Pt(H2L)2Cl2], [Pt(H2L)2Br2] structures, as well as tetramine [Pt(H2L)4]Cl2 types, were synthesized under various conditions. Studies indicate that in all the synthesized complexes, monoethanolamine is coordinated monodentately to the nitrogen atom of the amino group, and deprotonation of the hydroxyl group of the ligand does not occur. It was determined that the composition and structure of the obtained complexes are strongly influenced by the nature of the initial platinum salts and the synthesis conditions. For instance, when cis-[Pt(NH3Cl)2] is used as the initial platinum (II) salt, its interaction with monoethanolamine under specific conditions results in the formation of a cis-complex with the composition [Pt(H2L)2Cl2]. In an alkaline medium, the reaction of PtCl2 with monoethanolamine in a 1:10 ratio produces tetramine-type complexes [Pt(H2L)4]Cl2. The structure of the resulting trans-complex [Pt(H2L)2Cl2] was confirmed through X-ray diffraction analysis. Biological testing revealed that complexes I-IV exhibit varying levels of antitumor activity.
