Recent advances in direct 1,2-hydroxydifluoromethylation of olefins
نویسندگان
1 Urgench State Pedagogical Institute, Urgench, Uzbekistan.
2 Department of the History of Uzbekistan, Karshi State University, Karshi, Uzbekistan.
3 Department of Microbiology, Bukhara State Medical Institute, Bukhara, Uzbekistan.
4 Department of Chemistry, Andijan State University, Andijan, Uzbekistan.
5 Institute of Biochemistry, Department of Biotechnology, Samarkand State University, Samarkand, Uzbekistan.
6 Department of Basic Medical Sciences, Kimyo International University in Tashkent, Samarkand, Uzbekistan.
7 Department of Epidemiology, Infectious Diseases and Nursing, Fergana Medical Institute of Public Health, Fergana, Uzbekistan.
8 Department of Light Industry Technologies and Equipment, Faculty of Chemical Technologies, Urgench State University named after Abu Raykhan Beruni, Urgench, Uzbekistan.
9 Tashkent Institute of Chemical Technology, Tashkent, Uzbekistan.
10 Bukhara State University, Bukhara, Uzbekistan.
doi
10.22034/crl.2025.553447.1710چکیده
Due to its important role in drug discovery and its ability to significantly modify the physicochemical and biological properties of bioactive compounds, considerable research efforts have recently focused on the development of efficient and selective methods to incorporate the difluoromethyl group into organic molecules. In this context, the direct vicinal hydroxylative difluoromethylation of olefinic double bonds has emerged as an efficient one-step strategy for the synthesis of β-difluoromethyl alcohols from cheap and widely available starting materials. In this review, we provide an overview of the latest developments in this rapidly evolving field, aiming to stimulate further research and innovation.
