One-Pot multicomponent synthesis of substituted 1,6-naphthyridine derivatives employing 1-naphthylamine and SiO2/Fe3O4@ MWCNTs as organometallic catalyst
نویسندگان
1 Department of Chemistry, Qaemshhar Branch, Islamic Azad University, Qaemshhar, Iran.P
2 گروه شیمی دانشگاه آزاد اسلامی واحد قائمشهر
3 Department of Chemistry, Qaemshhar Branch, Islamic Azad University, Qaemshhar, Iran.
doi
10.22034/crl.2025.524526.1604چکیده
This research endeavor successfully synthesized 1,6-naphthyridine, an innovative category of fused heterocyclic compounds, with remarkable efficiency through the implementation of a multicomponent reaction. The reaction comprised benzaldehyde or its derivatives, two moles of malononitrile, and either 1-naphthylamine in an aqueous medium at ambient temperature, utilizing SiO2/Fe3O4@ MWCNTs as a recyclable catalyst. This investigation further explores the antioxidant characteristics of 1,6-naphthyridine in conjunction with the additional research conducted within this study. The synthesis protocol for 1,6-naphthyridine exhibited numerous advantageous attributes, encompassing expedited reaction times, elevated yields of the final product, and the ease of separating both the catalyst and product from the reaction mixture.
