Synthesis and characterization of some thiazole rings derived from theophylline and study of their antibacterial activity
نویسندگان
1 Education Rusafa First, Ministry of Education, Baghdad, Iraq.
2 Salah aldiyn Education, Ministry of Education, Baghdad, Iraq
3 Department of Medical Laboratory Technical, Technical institute Suwaira - Middle Technical University, wasit, Iraq.
doi
10.22034/crl.2025.488938.1475چکیده
Methylxanthine-derived theophylline is a well-known bronchodilator medication with additional anti-inflammatory and immunomodulatory properties theophylline is mixed with thiourea and aldehydes in ethanol to form the new compounds, which are subsequently synthesized by 4-bromophencylbromide closing the ring. Utilizing thin-layer chromatography, to assess the products' purity by TLC. Melting point measurements, FT-IR spectroscopy, H-NMR, C13-NMR, for final compounds, have all been used to characterize and confirm the chemical composition of intermediate and terminal compounds. The initial investigation of antibacterial activity, which involved five distinct bacterial strains, revealed that
