Direct vicinal oxy-azidation of unsaturated carbon-carbon bonds: a facile synthetic route to α-azido ketones
نویسندگان
1 Faculty of Engineering and Technology, Datta Meghe Institute of Higher Education and Research, Sawangi (Meghe), Wardha. India
2 Department of Applied Chemistry, Yeshwantrao Chavan College of Engineering, RTM Nagpur University, Nagpur, India
3 Department of Chemical Engineering, Termez State University of Engineering and Agrotechnologies.
4 Payame Noor University, Tehran, Iran
5 Centre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, 140401, Punjab, India
doi
10.22034/crl.2025.503463.1534چکیده
α-Azido carbonyls include compounds that are known to possess wide range of biological activities or are important templates in medicinal chemistry. They are also extremely powerful building blocks for the efficient synthesis of diverse arrays of biologically important N-heterocyclic compounds. In the light of the importance of this family of organic azide compounds a great deal of attention has been given to their synthesis and, in the past years, several methods have been described in the literature allowing for the direct construction of these substances from easily accessible alkene and alkynes by vicinal oxy-azidation reactions. However, no comprehensive review on this chemistry has been published to date. In this light, here we intend to summarize the advances in this attractive field with special attention on mechanistic features of the reactions.
