Recent advances in the construction of β-hydroxy phosphorus compounds via direct vicinal hydroxy-phosphorylation of alkenes
نویسندگان
1 Department of Engineering Science, College of Engineering, University of Tehran, Tehran, I.R. IRAN
2 Department of Engineering and Applied Sciences of Azerbaijan State University of Economics (UNEC), 194 M.Mukhtarov str., Baku AZ1065 Azerbaijan
3 Department of Engineering and Applied Sciences of Azerbaijan State University of Economics (UNEC), 194 M.Mukhtarov str., Baku AZ1065 Azerbaijan
4 Department of Engineering and Applied Sciences of Azerbaijan State University of Economics (UNEC), 194 M.Mukhtarov str., Baku AZ1065 Azerbaijan
5 Centre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, 140401, Punjab, India
doi
10.22034/crl.2025.501726.1528چکیده
β-Hydroxy phosphorus compounds are often encountered in numerous pharmaceuticals and bioactive molecules, and also of great importance as intermediates or building blocks in organic synthesis. Among various synthetic strategies developed, direct vicinal hydroxy-phosphorylation of easily accessible alkenes proves to be one of the most powerful and straightforward protocols to construct such privileged structures. In this review, we summarize the recent advances in the synthesis of titled compounds through the direct hydroxy-phosphorylation of alkene substrates using P(O)–H compounds, and underline the remaining challenges. This information would provide important and inspiring guidance for the researchers working in organophosphorus chemistry.
