فهرست نشریات علمی دسترسی آزاد ایران

Background: Surgery through different mechanisms causes immunosuppression in the postoperative period. Objectives: This study aimed to investigate the effects of preoperative administration of propranolol on blood levels of interleukin-2 (IL-2), interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), and hematological parameters, such as white blood cells (WBCs) and lymphocytes. Methods: Forty-five Wistar male rats were divided into three groups. Group 1 (normal control) was injected with normal saline. Groups 2 and 3 were injected subcutaneously with 4 mg/kg of the propranolol (P4) and 8 mg/kg of the propranolol (P8), respectively. Blood samples were collected (before, immediately, 6, 24, and 72 hours after surgery). Then, the IL-2, IFN-γ, TNF-α, WBCs, and lymphocytes levels were determined at different time points. The data were analyzed by one-way ANOVA and the Pearson-test at a significant level of P≤0.05. Results: The results showed a higher level of IL-2 in the P8 and P4 groups with a significant difference compared to the control group (P≤0.05). TNF-α was decreased significantly in the P8 compared to the P4 and control groups (P≤0.05). The P4 has shown a lower level of IFN- γ compared to the P8 and control groups with a significant difference (P≤0.05).Conclusion: It appears that propranolol has considerable immunomodulatory effects on immune responses. Therefore, perioperative use of propranolol may improve immune system function.