Synthesis of new schiff base compounds based on Tröger’s base contain thiadiazole amine and study antioxidant activity
نویسندگان
1 Department of Chemistry, College of Science for Women, University of Babylon, Hilla, Iraq.
2 Department of Chemistry, College of Science for Women, University of Babylon, Hilla, Iraq.
3 Department of Chemistry, College of Science for Women, University of Babylon, Hilla, Iraq.
doi
10.22034/crl.2024.472458.1398چکیده
In this study to prepare a new thiadiazole derivatives, a series of new five-heterocyclic compounds membered containing Schiff bases 5,5'-(6H,12H)-5,11- Methanodibenzo [b,f] [1,5] diazocine-2,8-diyl)bis(1,3,4-thiadiazol-2-amine) were synthesized from reactions [Methanodibenzo [6H,12H]-5,11- [b,f] [1,5] diazosine-2,8-dicarboxylic acid] and thiosemicarbazide in the presence of phosphorus oxychloride, which react with different aldehyde to synthesis compounds. In addition, the physical properties of the previously prepared compounds were studied, including melting points, as well as the evaluation of antioxidant activity. The characterization of the compounds was evaluated using (FTIR), (¹HNMR), (¹³C-NMR), and Mass spectroscopy. The results were evaluated for all prepared compounds and showed a strong ability to eliminate DPPH free radicals, ranging between (69.05% - 77.42%) and at high concentrations (1 mg/ml), as the compounds manufactured in this way can serve as promising candidates that need more research. From development as antioxidant agents.
