Potential anticancer activity and staining of tissue by new azo pyridyl dye and its palladium complex
نویسندگان
1 Department of Chemistry, Science College, University of Al-Qadisiyah, Al-Qadisiyah,
2 Chemistry department, Science college, University of Al-Qadisiyah, Iraq
doi
10.22034/crl.2024.467690.1379چکیده
Heterocyclic azo dye namely methyl (E)-4-hydroxy-3-(pyridin-3-yldiazenyl)benzoate (MHPDB) has been synthesized from 3-aminopyridine which serves as the diazonium salt and coupling with methyl 4-hydroxybenzoate component to form the dye. The palladium complex was synthesized by reacting two equivalent of MHPDB ligand with an equivalent of palladium chloride. The synthesized compounds were characterized by H-NMR, IR, UV-Vis spectroscopies and elemental analysis. The MHPDB ligand is bidentate based on infrared data and the palladium complex is square planer. The UV−Vis spectral demonstrate that the heterocyclic dye MHPDB shows red shift in basic medium comparison with the acidic medium where the backbone of dye owing better electron delocalization for heterocyclic system in basic medium. The synthesized compounds exhibited potential anticancer activity against A375 cell line. The IC50 of palladium complex was 66.44 g/mL against A375 cell line while its IC50 was 137.0 g/mL against HdFn health cell. The synthesized commands showed very good staining for ovary, uterus and intestine in mice.
