فهرست نشریات علمی دسترسی آزاد ایران

The synthesis and bioactivity assessment of 2-hydroxy-5-(naphthalene-1-yldiazenyl) benzaldehyde (HNDB) on lung cancer and esophageal cancer were investigated. The study aimed to evaluate the biological efficiency of HNDB through various applications and measurements. Previous research on HNDB's efficacy against breast lesions from early lactation human milk and esophageal cancer using the HBL-100 and SKGT-4 cell lines, respectively, was reviewed. HNDB demonstrated significant inhibitory effects on breast and esophageal cancer cells, with optimal concentrations of 500 µg/ml and 250 µg/ml, respectively. Moreover, its effectiveness against lung carcinoma using the A549 cell line was explored, indicating an optimal concentration of 250 µg/ml. The study employed MTT assays to determine cytotoxicity and inhibition rates, revealing promising anti-proliferative activity of HNDB across various cancer cell lines. Furthermore, response curves illustrated concentration-dependent inhibition, with IC50 values ranging from 148.2 to 261.6 µg/ml. Box-plot correlations highlighted concentration-dependent inhibition patterns, emphasizing the significance of optimal concentrations in achieving maximal inhibitory effects. Overall, the findings underscore the potential of HNDB as a novel anti-cancer agent against lung and esophageal malignancies, warranting further exploration for therapeutic applications.