فهرست نشریات علمی دسترسی آزاد ایران

The aim of the study is to synthesize heterocyclic derivatives (five and seven membered) rings linked to an aromatic nucleus containing nitrogen, oxygen and sulfur in its structure. Schiff’s bases were used for the synthesis processes. 2-bromo-6-methylaniline was used as an aromatic amine to react with aromatic aldehydes (furfural and salicyldehyde) to prepare Schiff bases (A and B) using ethanol as a solvent and glacial acetic acid as a catalyst, Schiff bases (A and B) were reacted with sodium azide using 1,4-dioxane as a solvent to obtain tetrazole derivatives (A1 and B1). Schiff bases (A and B) were also reacted with phthalic anhydride and using dry benzene as a catalyst to obtain oxazepine derivatives (A2 and B2). Schiff bases (A and B) were also reacted with thioglycolic acid and using 1,4-dioxane as a solvent to obtain thiazolidine derivatives (A3 and B3). All reactions were monitored using the thin layer chromatography technique (TLC). The physical properties of the prepared derivatives were obtained, and they were studied spectroscopically using FT-IR, 1H-NMR, and 13C-NMR techniques. The biological activity against Gram-negative Escherichia coli and Gram- positive Staphylococcus bacteria studied. The effect of the prepared derivatives was theoretically studied against the protein responsible for prostate cancer (1E3G) using MOLECULAR DOCKING software.