Direct hydroxyazidation of alkenes: A viable strategy for the synthesis of β-azido alcohols

نویسندگان
Hussein, Ali H. ID 1
Saud, Haider Radhi ID 2
Shahimi, Farinaz ID 3
Aldulaimi, Ahmed Kareem Obaid ID 4
Mohammed, Moayad Jasim ID 5
Bashir, Hala ID 6

1 Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq

2 National University of Science and Technology, Dhi Qar, Iraq

3 Department of Chemistry, Payame Noor University, P.O. Box 19395-3697 Tehran, Iran

4 College of Food Sciences, Al-Qasim Green University, Babylon, Iraq

5 Department of Pharmacy, Al-Noor University College, Nineveh, Iraq

6 Medical Technical College, Al-Farahidi University, Iraq

doi
10.22034/crl.2024.430494.1270
چکیده

The aim of this review is to summarize the available literature on the direct hydroxyazidation of alkenes, with particular emphasize on the mechanistic features of the reactions. The metal-catalyzed reactions are discussed first. This is followed by iodine- and enzyme-catalyzed reactions. Finally, the available examples on light-mediated reactions will be covered at the end of this review.

کلیدواژه‌ها
Difunctionalization, hydroxyazidation, β -azido alcohols, Alkenes, carbon-carbon double bonds, biocatalysts