Efficient Synthesis of β-Lactam-Containing α-Aminophosphonates Using Fumaric Acid as Mild Catalyst
نویسندگان
1 Department of Chemistry, Eurofins Advinus Ltd., 21 & 22, Phase II, Peenya Industrial Area, Bengaluru-560058, Karnataka, India
2 Department of Chemistry, Eurofins Advinus Ltd., 21 & 22, Phase II, Peenya Industrial Area, Bengaluru-560058, Karnataka, India
doi
10.22034/chemm.2018.66128چکیده
A short and efficient protocol for the synthesis of novel α-aminophosphonate esters containing β-lactam moiety is described. Inexpensive and mild catalyst such as fumaric acid was used for the synthesis of α-aminophosphonate esters by reacting N-(4-methoxyphenyl)-2-(substituted) propiolactam-3-carbaldehyde with amine and triethylphosphite in acetonitrile at reflux. α-aminophosphonate esters containing β-lactam hybrids were obtained in good yield and purity.A short and efficient protocol for the synthesis of novel α-aminophosphonate esters containing β-lactam moiety is described. Inexpensive and mild catalyst such as fumaric acid was used for the synthesis of α-aminophosphonate esters by reacting N-(4-methoxyphenyl)-2-(substituted) propiolactam-3-carbaldehyde with amine and triethylphosphite in acetonitrile at reflux. α-aminophosphonate esters containing β-lactam hybrids were obtained in good yield and purity.
