Lactobacillus Plantarum TWK-10 Single Strain Supplementation: Examining its Effects on Physical Performance, Physiological Metrics, and Fatigue-Related Parameters through a Systematic Review
نویسندگان
1 Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3 Service of Clinical Nutrition and Dietitian, Emam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
4 Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
doi
10.22038/jnfh.2025.85781.1558چکیده
Introduction: Physical activity has been observed to impact the diversity and composition of the microbiome. While existing research primarily concentrated on the influence of exercise on gut microorganisms and diversity, this systematic review seeks to explore the potential of TWK 10 probiotic supplementation on enhancing fatigue-related indicators among untrained individuals. Method: we conducted a comprehensive systematic review spanning the last decade (2013–2023), searching PubMed, Scopus, and Web of Science for both human and animal trials, with all searches completed by August 2023. Results: Eight clinical intervention studies that evaluated the impact of TWK-10 supplementation on diverse performance measurements and physiological parameters in both human and animals (totally consisting of 208 amateur athletes and 63 mice) were chosen. Intervention durations ranged from 6 to 18 weeks. Results from animal trials indicated that TWK-10 supplementation enhanced grip strength and endurance swimming time. Conversely, human trials did not reveal significant effects of TWK-10 on grip strength, glucose levels, muscle strength, body weight, or body composition. Inconsistencies were observed across studies regarding the impact of TWK-10 on serum levels of lactate, ammonia, glucose, creatine kinase (CK), and blood urea nitrogen (BUN). Some studies reported increased muscle mass and decreased fat mass following TWK-10 supplementation. Furthermore, TWK-10 administration evoked alterations in gut microbiota and concentrations of short-chain fatty acids. Conclusions: Further meticulously designed research is imperative to comprehensively ascertain the influence of TWK-10 supplementation on performance assessments and physiological parameters. Discrepancies in study outcomes may be attributed to disparities in fiber intake,gut microbiota composition and duration of the trials.
