فهرست نشریات علمی دسترسی آزاد ایران

Introduction: Oxygenated water intake can increase cell death markers by increasing free radicals; however, sport activities and antioxidant substances can prevent some symptoms of free radical production. The purpose of this study was to investigate the effect of endurance training (ET) and purslane (portulaca oleracea) seed (PO) consumption on cytochrome-C and malondialdehyde (MDA) in the heart tissue of rats poisoned with H2O2. Methods: Forty five male rats were randomly divided into 9 groups of 5 rats, including: 1)control, 2)50mg/kg PO, 3)200mg/kg PO, 4)400 mg/kg PO, 5)ET, 6)ET+50mg/kg PO, 7)ET+200mg/kg PO, 8)ET+400mg/kg PO, and 9)healthy control. During 8 weeks, groups 1-8 received 1 mmol/kg H2O2 intra-periton eally, three times per week, and groups 5-8 ran on treadmill for three days per week. Results: ET and PO significantly reduced cytochrome-C and MDA (p=0.001), however the interactive effect of ET and PO on the reduction of cytochrome-C (p=0.52) and MDA (p=0.08) was not significant; 200 mg/kg (p=0.01) and 400 mg/kg (p=0.001) PO significantly reduced cytochrome-C, as well as 400 mg/kg PO had more effect on the reduction of cytochrome-C than 200 mg/kg (p=0.01). Also, 400 mg/kg PO significantly reduced MDA (p=0.001). Conclusion: It seems that ET and PO improve cytochrome-C and MDA in the heart tissue of rats poisoned with H2O2.