فهرست نشریات علمی دسترسی آزاد ایران

Introduction: This study investigates the potential antiurolithiatic properties of two nutraceutical herbs, Amaranthus viridis and Capsicum annuum. Both herbs, known for their medicinal and nutritional benefits, has been explored for their role in preventing or treating kidney stone formation. Methods: Ethanolic extracts of Amaranthus viridis leaves and Capsicum annuum fruits were selected for evaluating anti-urolithiatic activity in Wistar rats due to presence of flavanoids, phenols, saponins and tannins. In-vitro assays was performed using aggregation and nucleation assay and in-vivo antiurolithiatic activity was performed by ethylene glycol induced urolithiasis model.Results: In-vitro results showed that both plant extracts and Cystone effectively inhibited nucleation and aggregation steps in kidney stone formation. The plant extracts demonstrated stronger inhibition during the aggregation phase, suggesting they may serve as a potent alternative or complement to cystone in preventing kidney stones. In-vivo evaluations using a glycol-induced urolithiasis model indicated that treatment with the extracts inhibited the increment in calcium and uric acid levels, thereby promoting a less acidic urinary environment. Serum analysis revealed reductions in creatinine and urea levels, indicating improved renal function. Kidney weight assessments and histopathological examinations of kidneys showed protective effects against hypertrophy and tissue damage. Conclusion: Findings suggested that Amaranthus viridis and Capsicum annuum possess significant antiurolithiatic property, supporting their potential as natural remedies for kidney stone prevention. Further research is recommended to isolate the active compounds and explore their mechanisms of action.