The Impact of Liraglutide on the Urogenital and Reproductive System in Mice
نویسندگان
1 Student's Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Cellular and Molecular Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran
3 Department of Genetics, Medical Branch, Islamic Azad University, Tehran, Iran
4 Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5 Department of Pathology, AshianGanoTeb Biopharmaceutical Company, Golestan University of Medical Sciences, Gorgan, Iran
6 Department of Electrical and Computer Engineering, University of Kashan, Kashan, Iran
7 Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
8 Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
9 Internal Medicine Department, School of Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
10 Department of Geriatric Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
11 Department of Biology, Khatam University, Tehran, Iran
12 Department of Biology, Medical Biotechnology Research Center, Yazd University, Yazd, Iran
13 Department of Anatomy, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
14 Department of Pathology, University of California, Los Angeles, USA
15 Department of Urology, Tehran University of Medical Sciences, Sina Hospital, Tehran, Iran
doi
10.22034/tru.2024.444725.1177چکیده
Introduction: We aimed to evaluate whether Liraglutide can remove the deteriorating impact of a high-fat diet (HF) diet on the genitourinary system.Methods: Fifty-six C57 mice were recruited of which received an HF as the intervention group, and a chow diet (CH) as a control group. After two months the case group was sub-grouped into three groups; 1: group HF with a daily injection of 0.4mg/kg liraglutide (HF+Lir), 2: CH with a daily injection of 0.4mg/kg liraglutide (CH+Lir), and 3: HF diet with an infusion of normal saline (HF+NS). After two months, all mice were sacrificed for additional testing.Results: Serological analysis showed no significant difference for lipid profile (P-value>0.05) and hormones except for PSA in males (P-value=0.019). This significance was seen when comparing CH+Lir and HF+NS to the control group (P-values=0.014 and 0.025, respectively). Liraglutide decreases testosterone in both genders and adiponectin and insulin in males. Total sperm count was decreased, and the difference between the groups was significant (P-value=0.013).Conclusions: Liraglutide cannot recover the deteriorating impact of an HF diet on sperm morphology and motility but can improve the sperm DFI and the total number of sperm.
