Investigating Kidney Pathologic Events in Nude Mice with Human Metastatic Breast Cancer
نویسندگان
1 Department of Pharmacology, AshianGanoTeb Biopharmaceutical Company, Gorgan, Iran
2 Department of Pharmacology, AshianGanoTeb Biopharmaceutical Company, Gorgan, Iran
3 Department of Veterinary Medicine, Baft Branch, Islamic Azad University, Kerman, Iran
4 Department of Anatomical Sciences, Golestan University of Medical Sciences, Gorgan, Iran
5 Sepehr Pathobiology Laboratory, Gorgan, Iran
6 Electrical Engineering Faculty, Najafabad Branch, Islamic Azad University, Isfahan, Iran
7 Cancer Research Centre, Johns Hopkins Institute, Maryland, USA
8 Department of Basic Sciences, Faculty of Veterinary Medicine, Ardakan University, Yazd, Iran
9 Department of Basic Sciences, Faculty of Veterinary Medicine, Ardakan University, Yazd, Iran
10 Department of Urology, Alborz University of Medical Sciences, Alborz, Iran
11 Iran University of Medical Sciences, Tehran, Iran
doi
10.22034/tru.2023.401907.1147چکیده
Introduction: Human metastatic breast adenocarcinoma is one of the most diagnosed cancers in females which can metastasize to other organs such as kidneys. So, we investigated the possible renal parenchymal changes in nude mice due to induced metastatic breast adenocarcinoma.Methods: 8 female mice were randomized into 2 groups. MDA-MB-231 subtype was injected in their left flank in the second group. Weight and tumor size were measured weekly. After euthanasia, tumoral and renal tissues were assessed by a pathologist.Results: The mean weight of the removed tumors was 2.04 grams (±0.05). Also, the mean weight of kidneys in G1 was 2.8±0.07 grams, and in G2 was 2.71±0.09 grams (P-value<0.05). Histopathological sections of renal parenchyma demonstrate normal and injured structures of the kidney tissue in groups 1 and 2, respectively. The thin arrow indicates the edema and the arrow head shows the hyperemia.Conclusion: There seems to be no statistically meaningful difference in renal changes and weight gain between normal and xenograft groups, but every 4 weeks’ measures show the tumor group a bit higher. There was no difference in metastasis pattern in both groups.
