The Impact of OPIUM and Its Derivatives on Cell Apoptosis and Angiogenesis
نویسندگان
1 Cancer Research Centre, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
2 Urology Research Centre, Tehran University of Medical Sciences, Tehran, Iran
3 Urology Research Centre, Tehran University of Medical Sciences, Tehran, Iran
4 Cancer Research Centre, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
5 Paediatric urology Department, Tehran university of Medical Sciences, Tehran, Iran
6 Genomic Research Centre (GRC), Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran
doi
10.22034/tru.2020.257910.1052چکیده
Opium is an opiate substance that significantly affects human physiology and behavior. Ancient priests used opium as a powerful healing drug, and many medical texts have referred to opium as medication, especially during the nineteenth century. In the old days, the medical use of opium was widespread and was called "God's medicine." On the other hand, understanding the molecular pathway of opium function within cells is essential from pathophysiological views and clinical applications. The current literature shows that opium can initialize cell death by activating apoptotic events, which in turn induces cascade pathways of angiogenesis. In this review article, we attempt to investigate the effects of opium on cell apoptosis and angiogenesis.
