Artificial Intelligence and Nanotechnology in Oral and Maxillofacial Cancer: A Review of Diagnosis and Treatment Advances
نویسندگان
1 Oral and Dental Disease Research Center, Department of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
2 Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Zanjan University of Medical Sciences, Zanjan, Iran
3 Private Practice, Dentist Lux Smile Dental Clinic, Mashhad, Iran
4 Department of Community Health and Health Behavior, State University of New York, SUNY, at Buffalo, U.S.
5 Department of Pediatric Dentistry, Faculty of Dentistry, Shahed University, Tehran, Iran
6 Department of Physics, Payame Noor University, Tehran, Iran
7 Department of Oral and Maxillofacial Surgery, School of Dentistry, Alborz University of Medical Sciences, Karaj, Alborz, Iran
doi
10.22034/nmrj.2025.03.001چکیده
Oral and maxillofacial cancer poses significant diagnostic and therapeutic challenges due to late-stage detection and treatment limitations. This review critically evaluates recent advances in artificial intelligence (AI) and nanotechnology applications for improving oral cancer diagnosis, treatment, and personalized patient care. Key diagnostic innovations include AI-powered image analysis, nanobiosensors, and nanoparticle-enhanced imaging modalities, which improve detection sensitivity and diagnostic accuracy. Treatment strategies integrating AI and nanotechnology focus on targeted drug delivery, multifunctional nanocarriers, and AI-optimized therapeutic regimens that enhance efficacy and reduce systemic toxicity. Emerging trends such as AI-controlled nanorobots and theranostic nanoplatforms show promising potential for advancing precision oncology. Challenges related to safety, ethical considerations, and clinical translation are also discussed. This comprehensive overview highlights how the synergy of AI and nanotechnology is poised to revolutionize oral cancer management, offering more effective, personalized, and less invasive options for patients.
