Modified Carboxymethyl Cellulose Containing Imine/Chitosan/ Nanoparticles: Synthesis and Study Biological Applications
نویسندگان
1 Department of Chemistry, College of Education for Pure Science Ibn Al-Haitham/University of Baghdad, Iraq
2 Department of Chemistry, College of Education for Pure Science Ibn Al-Haitham/University of Baghdad, Iraq
3 National Nanotechnology Open Laboratory, Al-Farabi Kazakh National University, Republic of Kazakhstan
doi
10.22034/nmrj.2025.03.006چکیده
The research deals synthesis of new organic compounds containing imine group and then modifying carboxymethyl cellulose (CMC) by reacting carboxymethyl cellulose with the prepared imine compounds and then mixing them with chitosan (CS) and nanoparticles (NPs) such as gold nanoparticles (AuNPs), magnesium oxide nanoparticles (MgONPs) and silver nanoparticles (AgNPs) and studying their important uses in biomedical fields. These prepared nanocomposites (modified CMC/CS/NPs) studied of antibacterial, anticancer and antioxidant activities. The toxicity of the nanocomposites was studied on mice, and histological analysis was performed in vitro. The results indicated that these nanocomposites had a larger diameter of growth inhibition zone compared to standard antibiotics (amoxicillin and tetracycline) and the antioxidant activity of modified CMC/CS/NPs showed a high inhibition rate compared to standard ascorbic acid. The nanocomposites showed excellent inhibition rates and were non-toxic against anticancer cells (A172), and compared to the normal cell line (REF). Molecular docking is used to determine the binding of the compounds to the enzyme and to determine the free energy (ΔG) of the synthesized compounds, so that they can be compared to the drug doxorubicin, making them useful in pharmaceutical manufacturing. Using H-NMR spectroscopy, FTIR, Transmission Electron Microscopy (TEM) and Field Emission Scanning Electron Microscopy (FESEM) the synthesized compounds were characterized.
