Physicochemical analysis of Magnesium Oxide Nanoparticles via Mango Peel Extraction approach: cytotoxic impact on MCF7 cell line
نویسندگان
1 Department of Biology, College of Education Pure Science, University of Diyala, Iraq
2 Department of Biology, College of Science, University of Baghdad, Iraq
3 Department of Biology, College of Education Pure Science, University of Diyala, Iraq
doi
10.22034/nmrj.2025.03.007چکیده
Objective(s): Sustainable bimetallic nanoparticles (NPs) have attracted a lot of attention in the past ten years. However, the environment and efficiency concerns are related to their synthesis and property optimization. Here, we describe the environmentally friendly synthesis of bimetallic MgONPs utilizing Mango Peel Extraction (MPE) and cytotoxic activities that show promise for anticancer potential against the MCF7 cell lineMethods: This work presents a green production of magnesium oxide nanoparticles (MgO NPs) using mango peel extract (MPE) as a stabilizing and reducing agent. The biosynthesized MgO NPs were comprehensively physicochemically characterized using techniques such as scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and UV-Vis spectroscopy. Results: Mango peel extract was used to successfully create magnesium oxide nanoparticles (MgO-NPs), as demonstrated by UV–Vis spectroscopy, which showed an absorption peak at about 362 nm. The majority of the nanoparticles were spherical, with diameters between 14 and 20 nm and a uniform dispersion, according to TEM and FESEM investigations. While FTIR analysis revealed the existence of –OH, C=O, and Mg–O functional groups, indicating efficient capping by bioactive chemicals from the extract, EDX spectra revealed magnesium and oxygen as the primary elements. With a GI²¹ value of roughly 11 µg/mL, cytotoxicity tests on the human breast cancer cell line MCF7 showed a dose-dependent decrease in cell viability. MgO-NPs caused 65.4% cytotoxicity at 25 µg/mL, along with significant morphological alterations like cell shrinkage and membrane integrity loss. These results indicate that MgO-NPs synthesized via mango peel extract possess significant anticancer potential.Conclusions: The bimetallic MgONPs that were successfully biosynthesized using MPE had significant biological engineering potential. Metal oxide nanoparticle biosynthesis is a great substitute for chemical synthesis.
