فهرست نشریات علمی دسترسی آزاد ایران

The formation of beads on electrospun nanofibers is commonly considered as a defect; therefore, researchers typically aim to produce bead-free nanofibers. Although several studies have investigated the parameters influencing bead formation, most have employed a one-factor-at-a-time approach, which is not ideal for capturing interaction effects among variables. In the present study, a Box–Behnken design was used to investigate the effects of solution concentration, applied voltage, and feed rate on bead formation. A total of 17 samples were prepared according to the design generated by the software, and bead formation on the samples was analyzed using scanning electron microscopy (SEM). The resulting data were subsequently used to develop a predictive model. The findings indicated that feed rate and applied voltage are the dominant factors, each exhibiting an optimal range required for the fabrication of bead-free fibers. In conclusion, bead-free nanofibers can be obtained through appropriate optimization of the applied voltage and feed rate.