فهرست نشریات علمی دسترسی آزاد ایران

Objective(s): The COVID-19 pandemic has underscored the global threat posed by opportunistic pathogens, including drug-resistant fungi. Metal nanoparticles are considered general microbicidal agents. These nanoparticles have a broad antimicrobial spectrum. Methods: The preparation of nanoparticles with curcumin coating was performed through a single-step procedure in which curcumin acted as a reducing and stabilizing agent. The characterizations of the particles were conducted through electron microscopy, dynamic light scattering, and UV-Vis spectroscopy. The cytotoxicity of particles was evaluated with an MTT assay. The antifungal properties of curcumin-coated gold nanoparticles were evaluated up to a concentration of 128 μg/ml against different species of Candida and Aspergillus, and compared with common antifungal drugs such as fluconazole and itraconazole. TEM was applied to investigate the structural analysis of the particles' interaction.Results: The particle synthesis was performed using a single-batch green method. Characterized by TEM, UV-Vis, and DLS, the particles exhibited an average diameter of 7.5 ± 4.1 nm and remained stable for over 64 days. Cytotoxicity tests on HepG2 cells showed high biocompatibility. While Cur@AuNPs exhibited antifungal activity against various species of Candida, including drug-resistant strains, no significant activity was observed against Aspergillus species. These findings suggest potential applications of Cur@AuNPs in treating Candida-related infections.Conclusions: Cur@AuNPs demonstrate inhibitory properties on different species of Candida but do not exhibit antifungal activity against either drug-sensitive or drug-resistant Aspergillus species.