فهرست نشریات علمی دسترسی آزاد ایران

Bacterial skin infection is a common clinical condition that impacts different organs. The emergence of antibiotic resistance is due to the overuse of antibiotics, which is rapidly increasing in developing countries. Due to the antibacterial properties of medical plants, they could be used as a treatment against various diseases like infectious diseases. The chemical composition of bergamot and pine essential oil (EO) was first investigated using GC-MS analysis. Nanoemulsion-based gels containing bergamot, pine, and a mixture of these EOs were then prepared. The viscosity of the nanogels was measured by viscometry. Attenuated total reflectance Fourier-transform infrared (ATR-FTIR) spectroscopy was employed to confirm the successful encapsulation of EOs within the nanogel matrix. Furthermore, the antibacterial effects of nanogels were investigated against Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) using the AATCC100 method. Linalool (48.50%), limonene (21.24%), linalool acetate (17.37%), α-terpineol (5.70%), and geranyl acetate (1.74%) were identified as significant bergamot compounds EO. The major constituents of pine EO were α-terpineol (66.69%), ɣ-terpineol (13.10%), terpinen-1-ol (11.15%), cis-β-terpineol (3.00%), and terpinen-4-ol (2.09%). The particle size of nanoemulsion containing bergamot EO, pine EO, and their mixture was measured as 34 ± 4 nm, 10 ± 2 nm, and 42 ± 6 nm, respectively. The viscosity of nanogels was fully fitted to the Carreau-Yasuda model. Interestingly, pine nanogel at 2000 µg/mL exhibited 95% growth inhibition against E. coli and S. aureus. Pine nanogel exhibited a favorable antibacterial effect against E. coli and S. aureus, so that it could be considered for further antibacterial investigation.