Electrochemical miRNA Biosensors: The Benefits of Nanotechnology
نویسندگان
1 Department of Textile and Polymer Engineering, Yazd Branch, Islamic Azad University, Yazd, Iran
2 Department of Nanobiotechnology/Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
3 Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
4 Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
5 Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
doi
10.22034/nmrj.2017.23336چکیده
The importance of nanotechnology in medical technologies, especially biomedical diagnostics, is indubitable. By taking advantages of nanomaterials, many medical diagnostics methods have been developed so far, including electrochemical nanobiosensors. They have been used for quantification of different clinical biomarkers for detecting, screening, or follow up a disease. microRNAs (miRNAs) are one of the most recent and reliable biomarkers used for biomedical diagnosis of various diseases including different cancer types. In addition, there are many electrochemical nanobiosensors explained in publications, patents, and/or a commercial device which have been fabricated for detection or quantification of valuable miRNAs. The aim of this article is to review the concept of medical diagnostics, biosensors, electrochemical biosensors and to emphasize the role of nanotechnology in nanobiosensor development and performance for application in microRNAs detection for biomedical diagnosis. We have also summarized recent ideas and advancements in the field of electrochemical nanobiosensors for miRNA detection, and the important breakthroughs are also explained.
