Application of Electrospun Nanofibrous PHBV Scaffold in Neural Graft and Regeneration: A Mini-Review
نویسندگان
1 Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences
3 Textile Engineering Department, Textile Excellence & Research Centers, Amirkabir University of Technology, Tehran, Iran
4 Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
5 Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences
doi
10.7508/nmrj.2016.02.007چکیده
Among the synthetic polymers, poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) microbial polyester is one of the biocompatible and biodegradable copolymers in the nanomedicine scope. PHBV has key points and suitable properties to support cellular adhesion, proliferation and differentiation of nanofibers. Nanofibers are noticeably employed in order to enhance the performance of biomaterials, and could be effectively considered in this scope. Electrospinning is one of the well-known and practical methods that extremely employed in the construction of nanofibrous scaffolds for biomedical application and recently PHBV has exploited in nerve graft and regenerative medicine. PHBV composites nanofibrous scaffolds are able to be applied as promising materials in many fields, such as; wound healing and dressing, tissue engineering, targeted drug delivery systems, functional carries, biosensors or nano-biosensors and so on. In this mini-review, we attempt to provide a more detailed overview of the recent advances of PHBV electrospun nanofibers application in neural graft and regeneration.
