فهرست نشریات علمی دسترسی آزاد ایران

Introduction & Objective: Tranexamic acid is a synthetic antifibrinolytic drug that reduces bleedingand transfusion requirements in cardiac surgery and total knee arthroplasty. In this study, we evaluated theefficacy of the prophylactic tranexamic acid to reduce intraoperative bleeding and improving visual field ofthe surgeon in patients undergoing lumbar hernial disc resection, anesthetize with two different methods ofinhalation or total intravenous anesthesia.Materials & Methods: Eighty percent patients in ASA class I-II were randomized into 4 groups. Ingroup 1, anesthesia was achieved by total intravenous anesthesia and tranexamic acid was administered too.Other groups were: group 2, anesthesia by total intravenous anesthesia without tranexamic acid, group 3,anesthesia by halothane and tranexamic acid was administered and in group 4, anesthesia by halothanewithout tranexamic acid was achieved. Blood loss and surgeon's satisfaction were registered.Results: The amount of blood loss in each group was as follow:Group 1: 267.1 ± 177.3 ml; group 2: 656 ± 411.6 mlGroup 3: 357 ± 307.2 ml; group 4: 550 ± 406.7 mlThe least bleeding was recorded in group 1 which had a significant difference with group 2 (p=0.007) andgroup 4 (p=0.04) that tranexamic acid was not administered. Blood loss in group 2 and 4 was identical andhad no significant difference (p= 0.3). Surgeon's highest satisfaction was with group 1.No complications were registered in 4 groups.Conclusions: We concluded that administration of prophylactic tranexamic acid in patients undergoinghernial disc resection has the potential to reduce intraoperative bleeding and improving visualization of thesurgical field especially when administered with total intravenous anesthesia. The method of anestheticmanagement had no effect.