Proline-Glycine-Proline as a Potential Biomarker in Chronic Obstructive Pulmonary Disease and Cystic Fibrosis

نویسندگان
Ten Hoeve, Arne Lucas ID 1
Edwin Blalock, James ID 2
Gaggar, Amit ID 3
Roda, Mojtaba Abdul ID 4
Redegeld, Frank ID 5
Folkerts, Gert ID 6

1 Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands

2 Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA

3 Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA

4 Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands

5 Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands

6 Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands

doi
چکیده

The present review discusses the role of tri-peptide Proline –Glycine -Proline (PGP) as a potential player, biomarker and therapeutic target in this process.

کلیدواژه‌ها
Chemotactic factors, Cystic Fibrosis, Chronic Obstructive Pulmonary Disease, Extracellular matrix, Neutrophil activation praline, Interleukin-8 A and B, Serine ednopeptidases