Proline-Glycine-Proline as a Potential Biomarker in Chronic Obstructive Pulmonary Disease and Cystic Fibrosis

نویسندگان
Redegeld, Frank ID 1
Olkerts, Gert F ID 2
Blalock, James Edwin ID 3
Gaggar, Amit ID 4
Hoeve, Arne Lucas Ten ID 5
Roda, Mojtaba Abdul ID 6

1 Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands

2 Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands

3 Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA

4 Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA

5 Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands

6 Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands

doi
چکیده

The present review discusses the role of tri-peptide Proline –Glycine -Proline (PGP) as a potential player, biomarker and therapeutic target in this process.

کلیدواژه‌ها
Chemotactic factors, Cystic Fibrosis, Chronic Obstructive Pulmonary Disease, Extracellular matrix, Neutrophil activation praline, Interleukin-8 A and B, Serine ednopeptidases