Synthesis and Characterization of a Schiff Base Ligand Derived from Diacetyl Monoxime, and the Study of Its Ag(I) Nanocomplex and Evaluation of Their Biological Activity
نویسندگان
1 Ministry of Education General Directorate of Al-Qadisiyah Education, Diwaniyah, Iraq
2 Department of Chemistry, College of Education, University of Al-Qadisiyah, Diwaniyah, Iraq
3 Department of Chemistry, College of Education, University of Al-Qadisiyah, Diwaniyah, Iraq
doi
10.22052/JNS.2026.03.023چکیده
The work in this paper describes the preparation and characterization of a new Silver (I) complex that is bonded with a Schiff Base Ligand synthesized from Diacetylmonoxime. A full range of analytical techniques have been used to determine fully the structure and the physical properties of both the ligand and the resultant complex. These include FT-IR, UV-Vis, 1H and 13C NMR Spectroscopy, Mass Spectrometry and Elemental Analysis (C, H, N), Crystallographic (X-Ray Diffraction) and Morphological (Field Emission Scanning Electron Microscopy) studies of the solid state complex, Thermogravimetric Analysis (TGA) of the solid state complex’s thermal decomposition, and Atomic Absorption, Magnetic Susceptibility, and Molar Conductivity measurements for the determination of the complex’s key physical/chemical parameters. Biological activity, selectivity, and potential therapeutic efficacy of the ligand and the complex was examined in cytotoxicity studies with lung cancer cells (A549) and normal cells (WRL-68). Additionally, we conducted an antioxidant study with the DPPH free radical scavenger assay and compared the results to that of regular ascorbic acid.
