فهرست نشریات علمی دسترسی آزاد ایران

The current work intended to establish an ecologically friendly method for the manufacture of magnesium oxide nanoparticles (MgO NPs) utilizing Hylocereus polyrhizus (dragon fruit) peel aqueous extract and assess their biological potential. Initial phytochemical screening found flavonoids, phenolics, tannins, alkaloids, and saponins in the plant extract, suggesting its potential as a natural reducing and stabilizing agent. In the present study, UV-visible spectroscopy (UV-Vis), atomic force microscopy (AFM), field-emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR) were used to characterize our biosynthesized magnesium oxide nanoparticles. It was found that we have formed nanoparticles that are mainly spherical and display a nanoscale size distribution. Our work revealed that the synthesized nanoparticles have a dose-dependent antioxidant effect in the DPPH radical scavenging assay, achieving 59.33% at a concentration of 1 mg/mL, and also examined their response to multidrug-resistant burn infections caused by Pseudomonas aeruginosa. Increasing the nanoparticle concentration resulted in larger inhibitory zones, indicating their potential action. Results of biocompatibility testing indicated that the magnesium oxide nanoparticles we synthesized exhibited no hemolytic activity at any of the doses tested, demonstrating excellent biomedical safety. Our work indicates that magnesium oxide nanoparticles, synthesized from dragon fruit peel extract using green methods, exhibit significant antioxidant and antibacterial properties, potentially offering a novel approach to treating burn-infected wounds caused by resistant bacterial strains.