Synergistic Effects of Silver Nanoparticles with Tamoxifen for Breast Cancer: A Review
نویسندگان
1 Department of Data Transmission Networks and Systems, Urgench State University named after Abu Rayhan Biruni, Urgench, Uzbekistan
2 Department of English Linguistics, Bukhara State University, Bukhara, Uzbekistan
3 Department of Obstetric and Gynecology N3, Samarkand State Medical University, Samarkand, Uzbekistan
4 Department of Art Science, Karakalpak State University named after Berdakh, Nukus, Republic of Karakalpakstan
5 Fergana Medical Institute of Public Health, Fergana, Uzbekistan
6 Department of Russian Language and Teaching Methods, Tashkent State Pedagogical University, Tashkent, Uzbekistan
7 Department Information Technologies, Tashkent State Technical University named after Islam Karimov, Tashkent, Uzbekistane
8 Department of Economics, Namangan State Technical University, Namangan, Uzbekistan
9 Department of Agronomy, Navoi State University of Mining and Technologies, Navoiy, Uzbekistan
10 Department of Faculty and Hospital Therapy №2, Nephrology and Hemodialysis, Tashkent State Medical University, Tashkent, Uzbekistan
11 Department of Endocrinology, Bukhara State Medical Institute named after Abu Ali ibn Sino, Bukhara, Uzbekistan
12 Department of Therapeutic Dentistry, Andijan State Medical Institute, Andijan, Uzbekistan
13 Andijan State Technical Institute, Andijan, Uzbekistan
doi
10.22052/JNS.2026.03.043چکیده
Breast cancer remains a leading cause of morbidity and mortality worldwide, necessitating the development of novel therapeutic strategies to improve treatment outcomes. Tamoxifen, a selective estrogen receptor modulator, has been a cornerstone in hormone receptor-positive breast cancer therapy but is often limited by drug resistance and adverse effects. Silver nanoparticles (AgNPs) have emerged as promising nanomaterials due to their inherent anticancer properties, including apoptosis induction, reactive oxygen species (ROS) generation, and cell cycle disruption. Recent investigations suggest that the combination of AgNPs with tamoxifen can produce a synergistic effect, enhancing cytotoxicity while potentially reducing tamoxifen dosage and associated side effects. This review critically examines the mechanisms underlying this synergy, exploring AgNP synthesis methods, physicochemical characteristics, and their interaction with tamoxifen in preclinical models. By analyzing current findings, we highlight the potential of AgNP-based combinatorial therapy to overcome treatment limitations and improve therapeutic precision in breast cancer.
