فهرست نشریات علمی دسترسی آزاد ایران

Hydroxyapatite is the perfect biomaterial for Biomedical Application due to its hemocompatibility and biocompatibility, which have been seriously studied by several researchers. The present research focuses on the anti-biofilm, anti-oxidant, and anti-hemolytic properties of hydroxyapatite (HAp) nanoparticles produced using Senna italica in an environmentally friendly manner. This comes after it proved effective as an antibacterial agent against S.aureus, P.aeruginosa and E.cloacae bacteria isolated from postoperative endophthalmitis in a previous study. HAp-NPs exhibits anti-biofilm activity, resulting in the conversion of S.aureus, P.aeruginosa and E.cloacae from strong biofilm-forming bacteria to weak biofilms in vitro. The analysis of antioxidant properties revealed that the HAp-NPs demonstrated significantly higher radical scavenging activity (up to 89.41%) less than 5% hemolysis at the highest concentrations (175–250 mg/ml) of the nano-hydroxyapatite indicates that the sample is very hemocompatible. The platelets attached to the hydroxyapatite show no signs of activation or morphological alteration. The produced nano-hydroxyapatite is a highly hemocompatible biomaterial that may find use in biomedical applications, according to this study.