فهرست نشریات علمی دسترسی آزاد ایران

A novel nano ligand, N- (4-chloro-2-(((Z)-4-methoxybenzylidene)amino)-5-methylphenyl)-1-(4-methoxyphenyl) methanimine (MAPM), was created by the reaction(1mol) of 4-chloro-5-methylbenzene-1,2-diamine with (2 mol) 4-methoxybenzaldehyde in anhydrous ethanol. The nano mononuclear complexes of this ligand was created with Ni(II), Cu(II), Pt(IV), Pd(II), Ag(I), and Au(III) ions. The compounds were recognized by means of mass spectrometry, 1HNMR and 13C NMR spectroscopy, elemental analysis (C, H, N), atomic absorption, UV-Vis and (FT-IR), magnetic susceptibility and molar conductivity as well as XRD and FE-SEM, revealed the nanoscale properties of the compounds. The measured data regarding the composition of the metal complexes and the elemental analysis confirmed that the ratio of metal to ligand is of the type [M(L)], where M is Pd(II), Ag(I), Au(III) and [M(L)2], where M is Ni(II), Cu(II), Pt(IV) and (MAPM) is a azomethine ligand. Previous measurements from tetrahedral geometry for Ag(I) complexes, square planar for Au(III) and Pd(II)complexes while the other complexes are  an octahedral geometry for Ni(II),Cu(II)and Pt(IV)ions are discussed. All complexes exhibited non-electrolytic characteristics, except for the silver and gold complexes, which were conductive. The compounds also demonstrated a high degree of temporal stability and effective inhibitory activity towards two bacteria that are pathogenic, S. aureus and E. coli. The investigation also included the in vitro assessment of the toxicity of MAPM and its Pd(II) complex towards human prostate cancer cells (PC-3) and other cells that are normal. Compared to the ligand, the Pd(II) complex has a higher affinity for cancer cells, it has no effect on non- cancer cells.