فهرست نشریات علمی دسترسی آزاد ایران

This study aimed to investigate the antimicrobial efficacy of a novel zein-coated magnesium oxide (MgO) nanogel at three concentrations (0.5%, 1%, and 1.5%) against key oral and periodontal pathogens. Two Gram-negative and one Gram-positive bacterium frequently linked to periodontal infections, Escherichia coli and Staphylococcus aureus, were among the species tested.  To test antibacterial activity, the agar well diffusion technique was used to measure inhibition zones. Antimicrobial activity increased with concentration. The 1.5% nanogel had the greatest mean inhibition zones against both bacterial strains.  The statistical test using one-way ANOVA verified that there were notable variations in the concentrations (p < 0.001). Boxplot analysis further illustrated a clear upward trend in inhibition zone diameters with increasing nanogel concentration. The findings suggest that zein-coated MgO nanogel demonstrates promising dose-dependent antimicrobial activity and may serve as an effective adjunct in the management of periodontal pathogens.