فهرست نشریات علمی دسترسی آزاد ایران

The poly (lactic acid) (PLA) nanofilm reinforced with zirconia nanoparticles (synthesized in green) and curcumin was created by solvent casting to form a biodegradable composite nanofilm. The X-ray diffraction identified the amorphous structure of PLA and the determination of the monoclinic reflectance of zirconia at the 2θ = 28.18° and the crystalline peak of curcumin at the 2θ = 28.18° with crystalline size of nanometers. As can be seen with the scanning electron microscopy (FE-SEM), there was an even surface with no cracks and a well- dispersed zirconia and curcumin nanoparticles integrated into the PLA structure. Microscopic observations revealed that there were fine nanoscale structures and topography which were slightly rough, which was evidence that the nanofillers were in good compatibility with the polymer chains. Nanoscale dispersion was detected by EDX analysis and it predominantly had carbon and oxygen signals with low level of zirconium content (0.07%). Fourier transform infrared spectroscopy (FTIR) analysis revealed the presence of functional groups such as the PLA ester (C=O at 1719 cm-1), the C=C aromatic curcumin (1510 cm1) and the Zr -O (592 cm1). The colony-forming unit (CFU) assay of antimicrobial activity showed a high level of biological activity, a 100 percent inhibition of Staphylococcus aureus and Candida albicans, and an 84 percent reduction of Escherichia coli colonies, and the synergistic effect of zirconia and curcumin in the PLA film.