فهرست نشریات علمی دسترسی آزاد ایران

Erythromycin (ERY) is one of the macrolid antibiotics used for the treatment of various infections caused by bacteria. Nanoparticles (NPs) can enhance the delivery and efficacy of erythromycin in the blood stream. Investigating the electrochemical characteristics of erythromycin nanoparticles (ERY NPs) in blood medium can provide insights into their interactions, stability, and overall efficacy. This study aimed to characterize the electrochemical behavior of ERY NPs in simulated blood medium at varying concentrations and pH levels, and to evaluate their stability, release kinetics, and interactions with blood components. The micro form of erythromycin was converted to nano form by lyophilization (freeze-dried) technique. The characteristics of new formed ERY NPs were detected by several microscopic and spectroscopic techniques, including atomic force microscopy (AFM), field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), Fourier transform infrared (FTIR) and Ultraviolet–visible (UV-Visible). Fresh human blood was used and different PH levels were adjusted (normal, acidic and basic levels) for the blood medium. All electrochemical investigations in blood medium were done by cyclic voltammetry instrument. Microscopical examination of the ERY-NPs by FESEM and AFM reveal the bars-like shape with an average diameter of about 40 - 46 ƞm. FTIR, UV-visible, and XRD spectroscopy showed that the nanoparticles were crystalline in nature, which is what erythromycin looks like in bulk. The cyclic voltammetry profiles of ERY-NPs in blood medium at different concentrations and pH levels showed significant shifts in the anodal and cathodic highest currents. Significant variations were demonstrated in the electrochemical properties of ERY NPs, which are affected by the blood medium composition, different pH levels, and nanoparticle concentration, providing insights into their performance as antibacterial reagents.