Formulation and Characterization of Solid Lipid Nanoparticle Loaded with Selexipag as Model Drug
نویسندگان
1 Najaf Health Directorate, Najaf, Iraq
2 Department of Pharmaceutics, Faculty of Pharmacy, University of Kufa, Najaf, Iraq
doi
10.22052/JNS.2026.01.060چکیده
The objective of this study was to formulate and characterize selexipag-loaded solid lipid nanoparticles by using the ultrasound method, with four types of lipids (Palmitic acid, Stearic Acid, Glyceryl dibehenate, and Glyceryl Monostearate) evaluated for their impact on the solubility, the release behavior, and the potential improvement in oral bioavailability. Different variables like lipid concentration and lipid type used to optimize the formulation to achieve desired particle size along with maximum entrapment efficiency percentage and cumulative drug release percentage. The interaction between all the variables is well studied. Nineteen formulations of selexipag-loaded solid lipid nanoparticles were prepared and optimized by design of expert software version 13. The optimized formulation (made by 150mg of glyceryl monostearate, 90mg of poloxamer 407) showed the particle size 105±5 nm, the entrapment efficiency of 93% and the cumulative drug release percentage of 80.8% after 24hrs. The kinetic of release best fitted the first order kinetic model.
